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Here's a look at documents from U.S. and international businesses
Featured Stories
Littler Issues Commentary: Bill Proposes Changes to Australia's Fair Work Commission Procedure and General Protections Provisions
SAN FRANCISCO, California, June 9 -- Littler, a law firm, issued the following commentary on June 8, 2026, by counsel Michael Whitbread and shareholder Naomi Seddon:
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Bill Proposes Changes to Australia's Fair Work Commission Procedure and General Protections Provisions
On June 3, 2026, the Australian Government introduced into Federal Parliament the Workplace Relations Legislation Amendment (Building Cooperative Workplaces No. 1) Bill 2026 (Bill). If passed, the Bill will amend Australia's Fair Work Act 2009 (FW Act), the Independent Contractors Act 2006, and the Fair Work (Registered Organisations)
... Show Full Article
SAN FRANCISCO, California, June 9 -- Littler, a law firm, issued the following commentary on June 8, 2026, by counsel Michael Whitbread and shareholder Naomi Seddon:
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Bill Proposes Changes to Australia's Fair Work Commission Procedure and General Protections Provisions
On June 3, 2026, the Australian Government introduced into Federal Parliament the Workplace Relations Legislation Amendment (Building Cooperative Workplaces No. 1) Bill 2026 (Bill). If passed, the Bill will amend Australia's Fair Work Act 2009 (FW Act), the Independent Contractors Act 2006, and the Fair Work (Registered Organisations)Act 2009 (FWRO Act).
Among the proposed changes, the Bill seeks to implement certain changes to the dismissal and unlawful termination provisions of the FW Act so that the Fair Work Commission (Commission) could begin dealing with a dispute based on an alleged dismissal or termination, without first determining whether a dismissal or termination in fact occurred. The proposed amendments appear to respond to the Full Federal Court case of Coles Supply Chain Pty Ltd v Milford [2020] FCAFC 152 where the Commission considered this issue.
The Bill also proposes to permit delegation of certain powers in unresolved dismissal and unlawful termination disputes to senior Commission staff. In addition, it would allow some matters to be determined on the papers where the Commission considers that appropriate and the parties consent.
The proposed changes sit alongside a new mechanism enabling the Commission, through a Full Bench, to restrict further applications by litigants whose earlier applications were dismissed, subject to procedural fairness requirements.
The Bill would further create a road transport contractor high-income threshold and align related provisions in both the FW Act and the Independent Contractors Act 2006. In addition, it would make it easier in certain circumstances to obtain a supported bargaining authorization for a replacement multi-enterprise agreement and would introduce reporting changes affecting the Construction and General Division under the FWRO Act.
Taken together, the amendments indicate a stronger emphasis on case management, procedural efficiency, and control of repetitive or unmeritorious filings, which is likely being driven by historically high case filings at the Commission and the increased reliance on AI by self-represented litigants.
Overall, the Bill is a technical reform package. Several proposed amendments--particularly those concerning Commission procedure, repeat applications, and procurement-related general protections exemptions--could have significant procedural and compliance consequences if enacted.
The Bill is in initial stages of its passage through Parliament so we may see amendments before it is passed in final form.
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Authors
Michael Whitbread
Of Counsel
New York
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Naomi Seddon
Shareholder
L.A. - Century City
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Original text here: https://www.littler.com/news-analysis/asap/bill-proposes-changes-australias-fair-work-commission-procedure-and-general
[Category: BizLaw/Legal]
Hughes Hubbard & Reed: Jeremy Paner Explains How Private Fund Managers Should Approach OFAC's Recent Advisory
NEW YORK, June 9 -- Hughes Hubbard and Reed, a law firm, issued the following news:
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Jeremy Paner Explains How Private Fund Managers Should Approach OFAC's Recent Advisory
Highlights
* OFAC's advisory warns that sanctioned parties are using proxies, family members and complex structures to obscure their ownership interests.
* Paner warns that OFAC will treat all private fund managers as "gatekeepers" and expects a clear explanation for any scenario in which red flags are raised.
* According to Paner, compliance must go beyond screening and application of the "50 Percent Rule."
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Speaking
... Show Full Article
NEW YORK, June 9 -- Hughes Hubbard and Reed, a law firm, issued the following news:
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Jeremy Paner Explains How Private Fund Managers Should Approach OFAC's Recent Advisory
Highlights
* OFAC's advisory warns that sanctioned parties are using proxies, family members and complex structures to obscure their ownership interests.
* Paner warns that OFAC will treat all private fund managers as "gatekeepers" and expects a clear explanation for any scenario in which red flags are raised.
* According to Paner, compliance must go beyond screening and application of the "50 Percent Rule."
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Speakingto Hedge Fund Law Report, Jeremy Paner analyzed the implications of the U.S. Department of the Treasury's Office of Foreign Assets Control's (OFAC) advisory warning of the growing use of sham transactions to evade sanctions.
The advisory highlights that sanctioned individuals and entities are increasingly using proxies, family members and complex structures to obscure ownership and continue transacting in violation of U.S. sanctions, while reinforcing that even seemingly remote connections will attract OFAC scrutiny in an increasingly aggressive enforcement environment.
Paner specifically discussed the impact of the advisory for PE and hedge fund managers.
"The importance of the Advisory is that it's a warning shot that OFAC will treat anyone that manages private funds as a gatekeeper," Paner said. "Anybody involved in private funds needs to have a good answer to any scenario in which red flags are raised. If a fund manager doesn't have an explanation, OFAC's enforcement response is going to be very aggressive."
He noted that OFAC's expectations extend beyond overreliance on screening and application of the "50 Percent Rule."
"When OFAC investigates a potential violation, the first thing the agency does is say, 'Hey, let's take a look at your compliance program.' They want to see what has slipped through the cracks," Paner said. "OFAC expects to see a compliance program that is commensurate with the specific risks that an entity faces and does not react well to a compliance program that is completely unable to mitigate the inherent risk."
Paner cited a January 2025 enforcement case, in which OFAC penalized Family International Realty and its U.S.-based owner, with a civil penalty exceeding $1 million over 73 violations of its Russia/Ukraine-related sanctions.
"What was really noteworthy for fund managers was that OFAC explicitly warned financial institutions that they have to conduct 'sufficient due diligence' to ensure that fund managers are not acting as proxies for sanctioned parties," Paner said.
Paner cautioned that OFAC expects firms to actively use information uncovered through routine business activities to identify potential sanctions risks.
"OFAC has always held the position that if an entity gets information in the ordinary course of its business, it needs to use that information [for compliance purposes]," Paner said. "But what some people are doing is conducting limited screening, considering the 50 Percent Rule and then burying their heads in the sand when it comes to emails received from the oligarchs."
"They're saying, 'Well, we did everything we could have,' but that's just not how it works."
Read the article (https://www.hflawreport.com/21447591/ofac-warns-of-growing-use-of-sham-transactions-in-sanctions-evasion-and-identifies-red-flags.thtml).
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Featured Lawyers
Jeremy P. Paner
Partner
Locations
Washington, D.C.
jeremy.paner@hugheshubbard.com
+1 (202) 721-4614
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Original text here: https://www.hugheshubbard.com/news-insights/insights/jeremy-paner-explains-how-private-fund-managers-should-approach-ofac-s-recent-advisory
[Category: BizLaw/Legal]
Gulfstream Strengthens International Sales Leadership Amid Increasing Worldwide Demand
SAVANNAH, Georgia, June 9 -- Gulfstream Aerospace, a subsidiary of General Dynamics, issued the following news release on June 8, 2026:
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Gulfstream Strengthens International Sales Leadership Amid Increasing Worldwide Demand
Appointments Across Europe, the Middle East, Africa and Asia-Pacific Support New Aircraft and Government Sales Growth
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Gulfstream Aerospace Corp. today announced a series of sales leadership appointments designed to support continued demand for its next-generation fleet across Europe, the Middle East and Africa (EMEA) and the Asia-Pacific region (APAC).
Marc Ghaly,
... Show Full Article
SAVANNAH, Georgia, June 9 -- Gulfstream Aerospace, a subsidiary of General Dynamics, issued the following news release on June 8, 2026:
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Gulfstream Strengthens International Sales Leadership Amid Increasing Worldwide Demand
Appointments Across Europe, the Middle East, Africa and Asia-Pacific Support New Aircraft and Government Sales Growth
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Gulfstream Aerospace Corp. today announced a series of sales leadership appointments designed to support continued demand for its next-generation fleet across Europe, the Middle East and Africa (EMEA) and the Asia-Pacific region (APAC).
Marc Ghaly,a nearly 20-year veteran of the business aviation industry, has been named division vice president of sales, reporting to Michael Swift, Gulfstream's group vice president of sales for EMEA and APAC. Ghaly brings extensive experience and leadership spanning engineering and global new aircraft sales to Gulfstream and is well positioned to lead the team amid growing worldwide demand for Gulfstream's next-generation fleet. Ghaly holds a bachelor's degree in mechanical engineering from Concordia University in Quebec, Canada, and is based in Dubai, United Arab Emirates.
Also based in Dubai, Jad Benhaijoub has been promoted to regional vice president of government sales for EMEA and APAC. Benhaijoub previously served as regional sales manager for EMEA and South Asia and joined the company in 2023. Prior to Gulfstream, he spent more than a decade at CAE in business aviation and helicopter training sales. He holds master's degrees in management and business administration from France's INSEEC School of Business and Economics and is a licensed private pilot.
"Marc and Jad bring a strong depth of leadership and international experience that will continue to strengthen our sales presence across these key regions," said Scott Neal, senior vice president of worldwide sales, Gulfstream. "Their expertise is well aligned with the growing demand we are seeing from both new aircraft and government customers."
To further support this growth, Gulfstream also appointed two new regional sales managers in Europe and the Middle East. Oliver Kuschka has been named regional sales manager for Central and Eastern Europe, the Commonwealth of Independent States (CIS) and Israel, while Omar Aker has been promoted to regional sales manager for the Middle East, Africa and Turkey.
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NOTE TO EDITORS
Inspired by the belief that aviation could fuel business growth, Gulfstream Aerospace Corp. invented the first purpose-built business aircraft, the Gulfstream I, which first flew in 1958. Today, more than 3,500 aircraft are in service around the world. Together with parent company General Dynamics, Gulfstream consistently invests in the future, dedicating resources to researching and developing innovative new aircraft, technologies and services. Gulfstream's next-generation family of aircraft, including the super-midsize Gulfstream G300, the category-leading Gulfstream G400, the award-winning Gulfstream G500 and Gulfstream G600, the ultralarge-cabin Gulfstream G700 and the ultralong-range Gulfstream G800, offers an aircraft for every mission. All are backed by the worldwide Gulfstream Customer Support network. Learn more at gulfstream.com.
More information about General Dynamics is available at generaldynamics.com.
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Original text here: https://www.gulfstreamnews.com/en/news/?id=2e672b5d-1dc1-4bc2-9d65-d4936dc33231
[Category: BizAerospace]
Global Toy Market Hits $123B as 'Play' Expands Across Ages and Markets
CHICAGO, Illinois, June 9 (TNSxrep) -- Circana, a company that says it is a leading advisor on the complexity of consumer behavior, issued the following news release:
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Global Toy Market Hits $123B as 'Play' Expands Across Ages and Markets
Adults, emerging markets, and digital behaviors are shaping the industry's future
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PARIS - The global toy industry is not only growing but transforming. According to Circana LLC's newly released 2026 Global Toy Report, the industry reached $123 billion in annual sales, growing +8% in 2025 - marking an inflection point as play evolves into a cross-generational,
... Show Full Article
CHICAGO, Illinois, June 9 (TNSxrep) -- Circana, a company that says it is a leading advisor on the complexity of consumer behavior, issued the following news release:
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Global Toy Market Hits $123B as 'Play' Expands Across Ages and Markets
Adults, emerging markets, and digital behaviors are shaping the industry's future
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PARIS - The global toy industry is not only growing but transforming. According to Circana LLC's newly released 2026 Global Toy Report, the industry reached $123 billion in annual sales, growing +8% in 2025 - marking an inflection point as play evolves into a cross-generational,cross-category behavior.
"The toy industry is not just growing - it's transforming," said Frederique Tutt, global toys industry advisor at Circana. "Play is expanded beyond childhood into a form of entertainment, creativity, and connection for all ages. The result is new demand across age groups and geographies, creating a more dynamic and resilient global toy market."
Adult Enthusiasm is Universal
While children under 10-years-old remain the market share majority, accounting for more than 65% of global toy sales, their share is gradually declining as older consumers assume a larger role. The fastest growth is coming from recipients aged 15 and older -- a segment that now represents nearly 20% of total toy sales and whose spending has more than doubled since 2020. Especially in developed markets, teens and adults are now responsible for the majority of incremental growth, driven by demand for collectibles, nostalgia-led purchases, and hobby-based play experiences.
Asia Surges Ahead
Every region is posting gains, but growth is strongest in Asia and Oceania. In fact, Asia has overtaken Europe to become the second-largest toy market globally, while North America remains the largest, accounting for 41% of total sales.
"We're seeing a dual-engine market take shape," added Tutt. "In emerging markets, rising populations, urbanization, and increasing spend per child are widening access to play. In developed markets, fandom and premiumization are reshaping value and expanding what play means."
Play is Always-On
Gen Alpha--the first fully digital-native generation--is discovering toys and making purchase decisions based on online content, creators, and social platforms, accelerating trend cycles and redefining how products gain relevance. At the same time, traditional category boundaries are blurring, with toys increasingly competing--and converging--with adjacent categories like video games, fashion, and beauty. Segments including licensed toys, building sets, games, collectibles, and plush are outperformers in the market as they resonate across lifestyles and experiences -- not just age groups.
"The future of the toy industry will be defined by how well brands adapt to a broader, more fluid definition of play," said Tutt. "Success comes from balancing innovation with meaningful engagement -- without losing sight of the joy and imagination which are the industry's superpowers in the first place. As more forms of entertainment compete for time and attention, play isn't becoming less relevant -- it's becoming essential."
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About Circana
Circana is a leader in providing technology, AI, and data to fast-moving consumer packaged goods companies, durables manufacturers, and retailers seeking to optimize their businesses. Circana's predictive analytics and technology empower clients to measure their market share, understand the underlying consumer behavior driving it, and accelerate their growth. Circana's Liquid Data(R) technology platform is powered by an expansive, high-quality data set, and intelligent algorithms trained on six decades of domain expertise. With Circana, clients can take immediate action to future-proof and evolve their growth strategies amid an increasingly complex, fast-paced, and ever-changing economy.
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Original text here: https://www.circana.com/post/global-toy-market-hits-123b-as-play-expands-across-ages-and-markets
[Category: BizConsulting]
CIAO Study: 11th Annual Longevity Symposium Provides New Peeks and Possibilities at Longer, Healthier Lives
LA JOLLA, California, June 9 -- Sanford Burnham Prebys issued the following news release on June 8, 2026:
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CIAO Study: 11th annual longevity symposium provides new peeks and possibilities at longer, healthier lives
The Cilento Initiative on Aging Outcomes (CIAO) held its 11th annual research symposium May 22 at Sanford Burnham Prebys Medical Discovery Institute, with more than a dozen scientists and physicians from Europe and the United States presenting new data and insights on human longevity and healthy aging.
The CIAO Study is international project to empirically identify key factors
... Show Full Article
LA JOLLA, California, June 9 -- Sanford Burnham Prebys issued the following news release on June 8, 2026:
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CIAO Study: 11th annual longevity symposium provides new peeks and possibilities at longer, healthier lives
The Cilento Initiative on Aging Outcomes (CIAO) held its 11th annual research symposium May 22 at Sanford Burnham Prebys Medical Discovery Institute, with more than a dozen scientists and physicians from Europe and the United States presenting new data and insights on human longevity and healthy aging.
The CIAO Study is international project to empirically identify key factors(biological, psychological and social) that promote healthy aging and extreme longevity. It is focused on the Natural Park of Cilento region in southern Italy, which is home to roughly 300 residents who are more than100 years old and in robust health.
(The broader region is notable for the long lives of its residents. It was the original source of research for Ancel Keys, the American physiologist who studied the influence of diet on health and first promoted the benefits of the Mediterranean diet.)
"Italy is among the longest-lived countries in the world. And nowhere is that more dramatically illustrated than in the Cilento region," said Salvatore Di Somma, MD, CIAO Study co-principal investigator and founder of Great Health Science, a network of public and private research organizations based in Rome, Italy.
"But living a long time in good health is the result of many, many factors not easily parsed. There are, of course, the basic characteristics, such as a healthy diet, exercise, a lifestyle of low stress and contentment, social engagement and ample sleep. But beneath these behavioral aspects lie the cellular hallmarks of aging, which we are seeking to identify and, if possible, therapeutically address."
Launched in 2015, the CIAO Study leverages the latest tools and technologies (genetics, epigenetics, transcriptomics, metabolomics, proteomics, stem cells, RNA biology and environmental analyses among them) to pinpoint why residents of Cilento live healthy lives decades past the global average life expectancy of 73.5 years.
Specifically, scientists from Sanford Burnham Prebys, an independent, nonprofit biomedical research institute in San Diego, the Sanford Stem Cell Institute at University of California San Diego, University La Sapienza in Rome and Great Health Science, have followed a distinct cohort of centenarians and controls living in and around the coastal town of Acciaroli, located in southern Italian approximately 85 miles south of Naples.
"Two major factors make the CIAO Study distinct and essential to better understanding human longevity and, more importantly, how we can all live longer, healthier lives," said David A. Brenner, MD, co-principle investigator and president and CEO of Sanford Burnham Prebys.
"First is the concentration of centenarians living in the Cilento region, who provide unprecedented opportunities to really dig into the how's and why's of their long lives. And second, unlike much of the current research and knowledge about centenarians and longevity, our work is based and supported by rigorous, standardized scientific methodologies and accurate clinical information. It is not anecdotal or speculative. We can test our hypotheses generated by measurements."
The CIAO Study is a cross-sectional, observational study consisting of two primary cohorts:
* 100 centenarians (age 95 and older) without dementia and 50 centenarians with diagnosed dementia
* 50 control participants (age 60-75) with no familial ties to the centenarians
* All reside within the Cilento region
All study participants provide regular blood samples for study, a clinical history and psychosocial assessment, a record of their nutritional habits and dietary patterns and undergo cognitive evaluation using standardized testing.
The collected blood samples are shipped to U.S.-based scientists for deeper analyses, including metabolomics, cytokines, biomarkers, proteomics, single nuclear multiomics, genomics and other biomedical technologies.
"This is where the CIAO Study really stands apart," said Tatiana Kisseleva, MD, PhD, a physician-scientist at UC San Diego School of Medicine and director of the Sanford Stem Cell Fitness and Space Medicine Center. "We are conducting the specific, targeted work necessary to inform and direct the next generation of studies and, ultimately, provide actionable answers, translating our findings into clinical solutions.
The May 22 symposium was a review and a preview, with CIAO Study researchers presenting early data and not-yet-published findings. Presentations were diverse. Among them:
* Aging is a time-dependent accumulation of interacting biological failures and cellular damage, said Paola Antonini, MD, PhD, of Great Health Science Italy. Aging is currently studied through the so-called "hallmarks of aging." The 12 current hallmarks are grouped into three categories: primary (genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and disabled macroautophagy), antagonistic (cellular senescence, mitochondrial dysfunction, deregulated nutrient-sensing) and integrative (stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis).
Antonini specifically discussed sirtuin-6, an enzyme and stress-responsive protein that regulates longevity. Studies in humans and other long-lived species have shown that enhanced DNA repair mechanisms coevolve with increased longevity.
Sirtuin-6 (SIRT6) may play a major role in this differential reparative efficiency across species.
SIRT6 functions as a nuclear NAD+-dependent deacetylase that epigenetically controls multiple stress, inflammatory, and metabolic pathways.
Fundamentally, damage to DNA is a unifying driver of aging, said Antonini. It contributes of many aspects, including tissue dysfunction and inflammaging, a state of chronic, low-grade and persistent inflammation that develops with age. Rather than healing an acute injury, the immune system becomes overactive yet inefficient, accelerating biological aging and increasing the risk of chronic diseases.
Antonini and others highlighted the critical importance of DNA methylation, an epigenetic process where chemical tags called methyl groups are added to the DNA molecule. This modification can turn genes "on" or "off" by changing gene activity without altering the underlying DNA sequence.
"DNA methylation Is the most critical epigenetic modification and plays a key role in regulating gene expression at cytosine-guanine sites (5-mCpG)," Antonini said.
* Sheldon Morris, MD, MPH, clinical professor and deputy director for the Sanford Stem Cell
- Clinical Center's CIRM Apha Clinic, highlighted some notable distinctions between centenarians (mean age: 96.1 years) and controls (mean age: 66.8 years):
- Centenarians' blood pressure tended to be lower, as was their weight and body mass index, particularly among men.
- Most centenarians (78.4%) have never smoked compared to controls (58.9%).
-A majority of centenarians (69.8%) do not consume alcohol compared to controls (32.7%).
- Most centenarians (91.6%) get five or more hours of sleep per night compared to controls (38%).
* Mean total cholesterol levels for centenarians studied was 164.8 compared to 187.5 for controls. (For most adults, an ideal total cholesterol level is less than 200 mg/dL.)
* Metabolic dysfunction is a natural part of aging. Over time, the human body simply works less efficiently and less well. Mohit Jain, MD, PhD, founder and chief scientific officer of Sapient, a San Diego-based biomarker discovery lab, investigates whether aging is, in fact, driven by metabolic change.
Jain and colleagues compared metabolites -- small molecules produced or used during metabolism -- in blood samples from centenarians and others. The researchers found that 10% of the 30,000 metabolites measured were significantly different in centenarians: 900 in increased levels, 1,900 in lower levels.
The findings provide another way to assess aging beyond simple chronology, Jain said. "This is a metabolic clock. Metabolically, people can appear decades older than their birthdate age." Centenarians, he noted, typically score years younger metabolically than their chronological age.
* Computational biologist Sanju Sinha, PhD, an assistant professor at Sanford Burnham Prebys, reported that plasma proteomics (a systematic analysis of all proteins circulating in blood) among centenarians mostly follow normal aging, with the exception of roughly 57 fibrosis-pathway enriched genes. One gene in particular stood out: SERPINE1, a protein-coding gene that provides instructions for making Plasminogen Activator Inhibitor-1, which acts as a primary regulator of blood clotting and cellular aging. Initial studies suggest lowering levels of SERPINE1 may lengthen lifespan and reduce liver fibrosis risk. SERPINE1 is already in clinical trials for its association with cancers and metabolic and blood disorders.
* Andreas Bergmann, PhD, founder and CEO of Waltraut Bergmann Foundation and PAM Theragnostics GmbH, discussed the rising importance and relevance of petidylglycine alpha-amidating monooxygenase or PAM, an enzyme solely responsible for the C-terminal amidation of peptide hormones and neuropeptides.
Amidation is the final and crucial step in the activation of more than 60 peptide hormones. PAM-activated peptide hormones regulate key physiological processes, such as organ function, neuronal signaling, metabolism and digestion, reproduction, emotions, growth and aging. Recombinant PAM was strongly efficient in preclinical models for restoration of blood-brain barrier (BBB), improvement of cerebral blood flow, reduction of amyloid load and improvement of cognition.
In a general population, reduced circulatory PAM activity leading to incomplete activation of peptide hormones is associated with an increased risk of developing dementia. Pilot data indicates that Cilento residents have elevated levels of PAM and subsequently more complete amidation/activation of peptide hormones. Compared to central European populations, an amidated peptide hormone called adrenomedullin that regulates endothelial function, blood-brain barrier function and microcirculation is higher in Cilento residents.
A recent study has shown that the "Cilento lifestyle" can significantly increase PAM and improve amidation in circulation. Determining PAM-levels and amidation status could be tools/endpoints for future longevity research, Bergmann said.
* Ludmil Alexandrov, PhD, professor at UC San Diego with joint appointments in bioengineering and cellular and molecular medicine, said CIAO centenarians appear to accumulate single point cell mutations and indels at lower rates in their genomes than controls. Indels are mutations caused by the insertion or deletion of bases in a DNA or RNA sequence. They are a fundamental type of genetic variation and different from point mutations where one base is simply swapped for another.
Alexandrov also noted that CIAO centenarians showed reduced telomere length attrition, suggesting slower hematopoietic or cellular aging. Telomeres are the protective, repetitive DNA caps at the ends of chromosomes. As people age and cells divide, these caps progressively shorten. The shortening serves as a biological clock, ultimately triggering cellular aging (senescence) and contributing to age-related diseases.
* Peter D. Adams, PhD, professor at Sanford Burnham Prebys, discussed cell senescence and aging. Cell senescence occurs when cells permanently stop dividing, but remain metabolically active. While senescent cells can act as a barrier to cancer, their accumulation with aging drives tissue dysfunction, chronic inflammation and age-related diseases.
Adams described experiments with aged mice using inhibitors of MDM2, a gene and protein involved in cell growth and DNA repair. He said MDM2 inhibitors appeared to rejuvenate the livers of aged mice, suppress frailty and extend their lifespan. The findings, he said, suggest that old mice can be used to test potential healthy aging interventions and that MDM2 inhibitors are candidates for healthy aging interventions in humans.
Click here (https://16515-my.sharepoint.com/personal/digitalmedialibrary_16515_onmicrosoft_com/_layouts/15/onedrive.aspx?id=%2Fpersonal%2Fdigitalmedialibrary%5F16515%5Fonmicrosoft%5Fcom%2FDocuments%2FDigital%20Media%20Library%20Documents%2FCommunications%20Team%20Projects%20Folder%2FDepartments%2FPhilanthropy%2FEvents%20and%20Programs%2FCIAO%2FCIAO%20Symposium%202026%2FCIA0%202026%20Program%2Epdf&parent=%2Fpersonal%2Fdigitalmedialibrary%5F16515%5Fonmicrosoft%5Fcom%2FDocuments%2FDigital%20Media%20Library%20Documents%2FCommunications%20Team%20Projects%20Folder%2FDepartments%2FPhilanthropy%2FEvents%20and%20Programs%2FCIAO%2FCIAO%20Symposium%202026&ct=1779903034246&or=OWA%2DNT%2DMail&cid=932fabc0%2D8744%2D8445%2D3aa1%2D79b37be9b964&ga=1) to see the full program for the May 22, 2026 CIAO 11th Annual Research Symposium.
Select past published research from the CIAO Study
* In a 2016 presentation, researchers reported that the oldest residents participating in the CIAO Study exhibited robust microcirculation of blood comparable in efficiency to people 30 years younger. They also noted that low blood levels of the peptide hormone adrenomedullin were an indicator for good microcirculation.
* In 2018, using a mix of scales to measure mental and physical well-being, resilience, optimism, anxiety, depression and perceived stress, researchers assessed 29 nonagenarians and 51 family members between the ages of 51 and 75.
They found the study participants aged 90 and older had worse physical health but better mental well-being than their younger counterparts. Exceptional longevity was characterized by a balance between acceptance of and grit to overcome adversities, along with a positive attitude and close ties to family, religion and the land, providing purpose in life.
* In 2020, a cross-sectional sampling of nonagenarians and centenarians, along with younger co-inhabitants from Cilento, evaluated key lifestyle, medical, echocardiographic and electrocardiographic features to identify the cardiovascular profile and lifestyle factors associated with longevity.
In contrast to their younger co-inhabitants, the older group did not smoke, had lower fasting glucose levels and lower LDL cholesterol despite being half as likely to be taking statins. They were physically active and enjoyed comparatively low levels of cardiovascular disease -- even persons with structural heart abnormalities experienced fewer symptoms.
* Also in 2020, researchers sought to define the neurocognitive profiles of 29 residents of the Cilento region at least 90 years old and 49 younger residents ages 50 to 75 years. They found that the older cohort appeared to enjoy cognitive status comparable to their younger cohabitants without significant differences in oxidative stress markers or the APOE genotype -- a genetic variation that determines a person's risk for developing certain diseases, particularly Alzheimer's. The authors concluded that the results might be related to the older group's optimal adherence to the Mediterranean diet, though other lifestyle factors and positive personality traits might be contributing to their healthy aging.
* In 2021, researchers investigating the relationship between loneliness and wisdom compared different age cohorts in San Diego and Cilento, using two validated loneliness scales. They found no significant differences in levels of loneliness among the groups, but a strong inverse correlation between loneliness and wisdom in all groups. Loneliness worsened general health, sleep quality and feelings of happiness, while wisdom improved these measures.
* In 2024, scientists compared the impact of a short-term Mediterranean diet on plasma metabolites, using demographically similar cohorts of Cilento residents versus persons living in Sweden. They found that even a 6-day dietary intervention involving a healthy Mediterranean diet significantly improved metabolic markers associated with cardiovascular disease in the Swedish participants.
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Original text here: https://sbpdiscovery.org/press/ciao-study-11th-annual-longevity-symposium-provides-new-peeks-and-possibilities-at-longer-healthier-lives/
[Category: BizHospital]
Bloomberg Law Names Dinsmore a Leading Law Firm
CINCINNATI, Ohio, June 9 -- Dinsmore and Shohl, a law firm, issued the following news release:
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Bloomberg Law Names Dinsmore a Leading Law Firm
Bloomberg Law named Dinsmore a "Leading Law Firm" in its 2026 rankings. Dinsmore earned the 13th spot in the "Large Firms" category.
For this year's rankings, Bloomberg factored in financial strength, talent and firm growth. It also weighted innovation and technology implementation.
"In today's environment, clients need more than legal counsel," said Dinsmore Managing Partner Josh Lorentz. "They need trusted advisors who understand their industries,
... Show Full Article
CINCINNATI, Ohio, June 9 -- Dinsmore and Shohl, a law firm, issued the following news release:
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Bloomberg Law Names Dinsmore a Leading Law Firm
Bloomberg Law named Dinsmore a "Leading Law Firm" in its 2026 rankings. Dinsmore earned the 13th spot in the "Large Firms" category.
For this year's rankings, Bloomberg factored in financial strength, talent and firm growth. It also weighted innovation and technology implementation.
"In today's environment, clients need more than legal counsel," said Dinsmore Managing Partner Josh Lorentz. "They need trusted advisors who understand their industries,anticipate challenges, and help them capitalize on opportunities. This ranking is a result of Dinsmore's commitment to investing in our people, expanding strategically, and continuing to elevate a collaborative culture that enables us to deliver practical, business-focused solutions wherever our clients need us."
Dinsmore has exponentially increased revenue in the last three years, reporting its highest earnings ever in 2025 with $443.8 million in total revenue.
The firm's focus on strategic growth is also reflected in its eight mergers and/or office expansions since 2020.
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Original text here: https://www.dinsmore.com/news/bloomberg-law-names-dinsmore-a-leading-law-firm/
[Category: BizLaw/Legal]
Agentic AI Success Starts by Reimagining Existing Processes, Says Research
CAMBRIDGE, Massachusetts, June 9 (TNSrpt) -- Pegasystems, a software company empowering digital transformation, issued the following news release:
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Agentic AI Success Starts by Reimagining Existing Processes, Says Research
Study finds organizations that achieve agentic AI success force cultural reset to maximize benefits and achieve consistent, predictable outcomes
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LAS VEGAS - Organizations delivering agentic artificial intelligence (AI) successfully do so by rethinking existing processes to support a culture of collaboration and innovation that maximizes project benefits, according
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CAMBRIDGE, Massachusetts, June 9 (TNSrpt) -- Pegasystems, a software company empowering digital transformation, issued the following news release:
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Agentic AI Success Starts by Reimagining Existing Processes, Says Research
Study finds organizations that achieve agentic AI success force cultural reset to maximize benefits and achieve consistent, predictable outcomes
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LAS VEGAS - Organizations delivering agentic artificial intelligence (AI) successfully do so by rethinking existing processes to support a culture of collaboration and innovation that maximizes project benefits, accordingto new research from Pegasystems Inc. (NASDAQ: PEGA), the enterprise AI software company for mission-critical work. The study, conducted with research firm Savanta, was unveiled at PegaWorld(R), the company's annual conference in Las Vegas. It identified more than 500 business and IT decision makers across enterprises worldwide who have already implemented agentic AI projects and surveyed them on the secrets behind their success.
The study revealed the vast majority (96%) of those who successfully implemented agentic AI had rethought existing processes, sparking a new culture of collaboration and innovation. More than half (53%) said they've done so to a 'significant' extent, by reimagining everything their organization does to gain maximum benefit from their agentic implementations. Eighty percent agreed business and IT were willing to embrace new technology, innovation, and ideas to explore new possibilities - a further sign of revisiting traditional ways of thinking and finding new ways to collaborate and ensure project success.
This newfound commitment to rethinking old methods to ensure success is driven largely by a desire to provide more consistent, predictable outcomes. Three quarters (71%) of successful agentic AI implementers said one of their top two pre-deployment objectives was to automate and simplify complex processes, so they work consistently and predictably across systems and platforms. Almost half (45%) ranked this as their top priority. Over half (58%) also reported their execution aligned with these objectives had already been rewarded with predictable outcomes, reduced complexity, and improved customer experiences.
Other findings from the research highlighted some of the key behaviors of those who have achieved agentic AI success, including:
* Clearly defined metrics and strategies: An overwhelming 95% of those who successfully deployed AI agents have a specific corporate-level strategy and plan for execution. Meanwhile, two thirds (65%) have comprehensive, pre-agreed success metrics tied to business outcomes that are regularly reviewed, so implementation success is continually evaluated.
* Understanding the impact: Almost two thirds (61%) said they start an agentic project with the expectation it will 'significantly' improve customer experience once fully integrated. And more than half (58%) said they begin agentic projects believing they will realize significant, measurable value - including the potential for both increased customer satisfaction and cost reduction.
* A little understanding goes a long way: The contrast is stark between those who understand and embrace agentic AI, and those who don't. When asked to name leading barriers to achieving a positive agentic project outcome, over three quarters (77%) pointed to lack of sufficient resources - a potential indicator of limited awareness of the value agentic AI can add to the business. In addition, three quarters (75%) agreed a lack of knowledge and understanding of the benefits agentic AI can bring to the business is the biggest barrier to agentic AI success.
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Quotes & Commentary
"We're fast reaching a tipping point with agentic AI where adoption is high within organizations, but maturity is not," said Don Schuerman, chief technology officer, Pega. "The value will come from rethinking ways of working and aligning culture around what AI makes possible. Those changes are what separates the promise of AI technology from the reality of creating truly transformational benefits.
The winners in the agentic era will not be those who deploy agents wherever and whenever they can. They will be those who reimagine themselves and find new ways to give clients and their customers what they want. Businesses that don't will be left behind."
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Notes
Pega surveyed more than 500 business and IT decision makers worldwide who had successfully implemented agentic AI projects. It explored their motivations for embracing the technology, the most common factors in delivering success, and barriers to achieving their goals. The results included responses from North America, the United Kingdom, France, Australia, and Germany.
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REPORT: https://www.pega.com/system/files/resources/pdf/pega-the-truth-about-agentic-ai-success.pdf?_rid=YToyOntzOjQ6ImxhbmciO3M6MjoiZW4iO3M6NzoiY29udF9pZCI7czoxMToiQ09OVC0yOTQxNjgiO30-
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Original text here: https://www.pega.com/about/news/press-releases/agentic-ai-success-starts-reimagining-existing-processes-says-research
[Category: BizComputer Technology]
