Businesses
Here's a look at documents from U.S. and international businesses
Featured Stories
Skanska Awarded $1.06B Contract for North Station Draw One Bridge Replacement and Track & Signal Upgrades in Massachusetts
NEW YORK, May 7 -- Skanska, a construction and development company, issued the following news release:
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Skanska awarded $1.06B contract for North Station Draw One Bridge Replacement and Track & Signal Upgrades in Massachusetts
BOSTON, MA - Skanska, a leading global construction and development firm, today announced it has been awarded a contract by the Massachusetts Bay Transportation Authority (MBTA) to deliver the $1.06 billion North Station Draw One Bridge Replacement and Associated Track & Signal Upgrades project across Cambridge, Boston and Somerville, MA. The project will modernize
... Show Full Article
NEW YORK, May 7 -- Skanska, a construction and development company, issued the following news release:
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Skanska awarded $1.06B contract for North Station Draw One Bridge Replacement and Track & Signal Upgrades in Massachusetts
BOSTON, MA - Skanska, a leading global construction and development firm, today announced it has been awarded a contract by the Massachusetts Bay Transportation Authority (MBTA) to deliver the $1.06 billion North Station Draw One Bridge Replacement and Associated Track & Signal Upgrades project across Cambridge, Boston and Somerville, MA. The project will modernizea critical rail corridor serving more than 11 million riders a year and strengthen connectivity across the Greater Boston region. VHB, a leading engineering, planning, and design company headquartered in Watertown, MA, is the design partner for the design-build contract.
"We are proud to partner with the MBTA on this transformative infrastructure investment that will enhance reliability, and support the region's growing transit needs," said Paul Pedini, senior vice president of Skanska USA Civil. "By leveraging innovative design and construction solutions, our team will deliver a future-ready rail network while maintaining uninterrupted service for the passengers who rely on it every day."
"The replacement of the Draw One bridges is one of the most significant infrastructure investments in the MBTA Commuter Rail system," said Ricky Carey, design manager of VHB. "Once complete, these new structures will deliver lasting benefits to one of the region's busiest transportation corridors."
The scope of the project includes replacing the existing 1930-era Draw One bascule bridges with new vertical lift spans, significantly modernizing rail operations across the Charles River. The project also involves extensive upgrades to approach trestles, the construction of a new Tower A control facility and the addition of a new Platform F at North Station. These improvements are designed to streamline operations, enhance system flexibility and reliability, and support long-term ridership growth across MBTA's north-side commuter rail network.
In addition, the project encompasses comprehensive track, signal and Positive Train Control (PTC) upgrades to improve safety, resiliency and operational efficiency. The team will implement innovative Alternative Technical Concepts to reduce in-water work, simplify construction staging and enhance safety while maintaining continuous commuter rail and Amtrak service throughout the construction period. Upon completion, the corridor will expand from four to six tracks across the river, reducing congestion and improving reliability, with construction carefully phased to maintain commuter rail and Amtrak operations and minimize disruption to daily service.
Work is scheduled to commence this month, with expected completion in Fall 2032.
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About Skanska USA
At Skanska, we build for a better society. From hospitals to stadiums, airports to corporate headquarters, and power plants to tunnels and bridges, the important buildings and infrastructure we create help heal, transport, entertain and energize communities.
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About Skanska Group
Skanska is one of the world's leading project development and construction groups.
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Original text: https://www.usa.skanska.com/who-we-are/media/press-releases/306596/Skanska-awarded-1.06B-contract-for-North-Station-Draw-One-Bridge-Replacement-and-Track--Signal-Upgrades-in-Massachusetts/
[Category: BizConstruction]
Reto Moser Appointed General Manager of The Park Gstaad, A Four Seasons Hotel Ahead of Winter Opening
TORONTO, Ontario, May 7 [Category: TravelBiz] -- Four Seasons Hotels and Resorts posted the following news release:
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Reto Moser Appointed General Manager of The Park Gstaad, A Four Seasons Hotel Ahead of Winter Opening
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Four Seasons announces the appointment of Reto Moser as General Manager of The Park Gstaad, A Four Seasons Hotel, which is set to open in late 2026, ready for the winter season. Nestled in the heart of the Swiss Alps, the hotel will offer unparalleled luxury services for which Four Seasons is internationally renowned while continuing to reflect the heritage and rich history
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TORONTO, Ontario, May 7 [Category: TravelBiz] -- Four Seasons Hotels and Resorts posted the following news release:
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Reto Moser Appointed General Manager of The Park Gstaad, A Four Seasons Hotel Ahead of Winter Opening
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Four Seasons announces the appointment of Reto Moser as General Manager of The Park Gstaad, A Four Seasons Hotel, which is set to open in late 2026, ready for the winter season. Nestled in the heart of the Swiss Alps, the hotel will offer unparalleled luxury services for which Four Seasons is internationally renowned while continuing to reflect the heritage and rich historyof this iconic property.
Following extensive renovations managed by Squircle Capital and led by French interior designer Joseph Dirand, The Park Gstaad, A Four Seasons Hotel will welcome guests with 75 rooms and suites, including a collection of luxury Penthouse Residences. The new culinary offerings will include a total of seven restaurants and lounges - ranging from a modern live fire grill to Japanese omakase and Swiss classics. At the property, guests will enjoy a luxurious spa and fitness centre including two treatment rooms dedicated exclusively to Clinique La Prairie. The hotel will also feature both indoor and outdoor swimming pools, Kids For All Seasons, as well as Alpine Lounge and Alpine Concierge services, providing the opportunity to book personalized winter and summer activities.
"Being born and raised in Switzerland, Gstaad has always been very close to my heart," says Moser. "Some of my most memorable childhood days were spent skiing and exploring these mountains, and so returning here to open this iconic property is both deeply meaningful and a true honour. We're thrilled to introduce Four Seasons to this exceptional destination and to share the genuine warmth of Alpine hospitality, making every guest feel completely at home while enjoying the personalised service Four Seasons is celebrated for."
Moser brings more than two decades of international experience across Europe, the Middle East, and Asia. He joined Four Seasons in Provence in 2004, and over the years held positions in food and beverage operations in Bangkok and Koh Samui, before progressing into senior management roles in Cairo, Moscow, and Dubai.
Discreet Alpine Sanctuary with Effortless, Understated Luxury
Renowned as the first five-star hotel in Gstaad upon its opening in 1910, The Park Gstaad will be fully reimagined by Squircle Capital as a Four Seasons property, blending timeless Swiss elegance, mountain adventure and a refined international lifestyle. The hotel sits just a short walk from the famed Gstaad Promenade, home to gourmet restaurants, artisan food shops and fashion boutiques.
The Park Gstaad, A Four Seasons Hotel joins the Four Seasons collection of heritage properties in Europe, as well as the brand's collection of alpine properties, including in Megeve, Jackson Hole, Vail, Santa Fe, Whistler and upcoming projects in Deer Valley and Telluride.
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Original text here: https://press.fourseasons.com/gstaad/hotel-news/2026/the-park-gstaad-general-manager-reto-moser
NetApp Hosts Fourth Quarter and Fiscal Year 2026 Financial Results Webcast
SUNNYVALE, California, May 7 -- NetApp, a provider of software, systems and services to manage and store data, issued the following news release:
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NetApp Hosts Fourth Quarter and Fiscal Year 2026 Financial Results Webcast
SAN JOSE, Calif. - After market close on May 28, 2026, NetApp (NASDAQ: NTAP) will announce financial results for the fourth quarter and fiscal year 2026, which ended April 24, 2026.
NetApp executive management will host a conference call Webcast at 2:30 p.m. Pacific Time to discuss these results and provide their perspective on market dynamics.
How to Participate
The
... Show Full Article
SUNNYVALE, California, May 7 -- NetApp, a provider of software, systems and services to manage and store data, issued the following news release:
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NetApp Hosts Fourth Quarter and Fiscal Year 2026 Financial Results Webcast
SAN JOSE, Calif. - After market close on May 28, 2026, NetApp (NASDAQ: NTAP) will announce financial results for the fourth quarter and fiscal year 2026, which ended April 24, 2026.
NetApp executive management will host a conference call Webcast at 2:30 p.m. Pacific Time to discuss these results and provide their perspective on market dynamics.
How to Participate
Thelive Webcast call can be accessed at investors.netapp.com. Please allow at least 15 minutes prior to the start of the Webcast to log in. An audio replay Webcast will also be available after 4:30 p.m. Pacific Time.
NetApp Future Targeted Release Dates
Q1 FY 2027 results target date: September 2, 2026
Q2 FY 2027 results target date: December 1, 2026
Q3 FY 2027 results target date: March 4, 2027
Q4 FY 2027 results target date: June 3, 2027
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About NetApp
For more than three decades, NetApp has helped the world's leading organizations navigate change - from the rise of enterprise storage to the intelligent era defined by data and AI. Today, NetApp is the Intelligent Data Infrastructure company, helping customers turn data into a catalyst for innovation, resilience, and growth.
At the heart of that infrastructure is the NetApp data platform - the unified, enterprise-grade, intelligent foundation that connects, protects, and activates data across every cloud, workload, and environment. Built on the proven power of NetApp ONTAP, our leading data management software and OS, and enhanced by automation through the AI Data Engine and AFX, it delivers observability, resilience, and intelligence at scale.
Disaggregated by design, the NetApp data platform separates storage, services, and control so enterprises can modernize faster, scale efficiently, and innovate without lock-in. As the only enterprise storage platform natively embedded in the world's largest clouds, it gives organizations the freedom to run any workload anywhere with consistent performance, governance, and protection.
With NetApp, data is always ready - ready to defend against threats, ready to power AI, and ready to drive the next breakthrough. That's why the world's most forward-thinking enterprises trust NetApp to turn intelligence into advantage.
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Original text: https://www.netapp.com/newsroom/press-releases/news-rel-20260506-339377/
[Category: BizComputer Technology]
Mindtrip Launches Travel's First All-in-one Agentic AI Flight Booking Experience, Powered by Partnership With Sabre and PayPal
SOUTHLAKE, Texas, May 7 -- Sabre, a travel technology company, issued the following news release:
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Mindtrip launches travel's first all-in-one agentic AI flight booking experience, powered by partnership with Sabre and PayPal
From search to checkout, new conversation-led experience brings discovery, booking, and payments together, helping travelers instantly evaluate complex flight options and make smarter decisions in real time
At launch, consumers who book flights on Mindtrip can earn 5,000 PayPal points ($50 value*) when they spend $250+ using PayPal Buy Now Pay Later*
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San Francisco,
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SOUTHLAKE, Texas, May 7 -- Sabre, a travel technology company, issued the following news release:
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Mindtrip launches travel's first all-in-one agentic AI flight booking experience, powered by partnership with Sabre and PayPal
From search to checkout, new conversation-led experience brings discovery, booking, and payments together, helping travelers instantly evaluate complex flight options and make smarter decisions in real time
At launch, consumers who book flights on Mindtrip can earn 5,000 PayPal points ($50 value*) when they spend $250+ using PayPal Buy Now Pay Later*
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San Francisco,CA - Mindtrip, an AI-powered platform that empowers people to travel differently, today announced the launch of Mindtrip Flights, a new, conversation-led experience that makes it easier to find, compare, and book flights while making smarter decisions along the way.
Powered by Sabre's AI-native travel platform, Sabre Mosaic(TM), offering agentic-ready Air APIs and integrated with PayPal's agentic commerce services, Mindtrip Flights brings real-time flight options and booking into one seamless experience. Unlike traditional flight search tools that rely on filters and long lists of results, Mindtrip Flights removes the tedious tasks of having to manually piece together a variety of variables, travelers can simply "talk" to Mindtrip, whether planning a quick trip or something more complex, like coordinating a group flying from different cities.
Built to handle the complexity of modern travel planning, travelers can ask questions like "what are the cheapest flights for a ten-day trip to Paris in June" or compare options based on timing, budget, and convenience. By analyzing countless flight combinations behind the scenes, factoring in timing flexibility, routing nuances, and evolving traveler preferences, the experience delivers a concise set of structured, high-quality recommendations.
"Flight planning is one of the most complex and time-consuming parts of travel," said Andy Moss, CEO of Mindtrip. "Mindtrip Flights shows how agentic AI can simplify that complexity, moving travelers from overwhelming choice to clear, confident decisions. Travel is shifting from search to AI-assisted decision-making, and the platforms that win will be the ones that understand the traveler and deliver the best outcome at the right moment."
Mindtrip Flights also adapts to real-world scenarios, including different departure cities, alternate airports, and changing plans. It evaluates key tradeoffs, like price versus convenience or shorter travel time, to highlight the options that matter most, reducing the need for manual comparison. Over time, the platform learns from traveler preferences to deliver increasingly personalized recommendations.
"This is the moment the industry and its travelers have been waiting for with agentic AI," said Garry Wiseman, President of Product & Engineering at Sabre. "For the first time, we've truly bridged the gap between inspiration and purchase, allowing travelers to move from intent to transaction entirely within the same chat, rather than simply being redirected to book on a website. By anchoring real-time airline content and trusted payments into Mindtrip's consumer interface, we've moved agentic AI out of the lab and onto the ledger. It's no longer theoretical - it's a live production blueprint that paves the way for a new era of scalable, autonomous travel commerce." Wiseman added, "This isn't just a one-off project. The way we see it, it's an open invitation to the industry. If you're building the next great AI experience, we can make that a reality. We've created a blueprint for how the travel industry can come together to scale in the agentic era."
To get started, travelers visit mindtrip.ai/flights and begin planning through a simple conversation. When it's time to book, they can check out directly within the experience using PayPal, including their flexible options like Buy Now, Pay Later (subject to approval, terms apply) with both PayPal's Pay in 4 (https://www.paypal.com/us/digital-wallet/ways-to-pay/buy-now-pay-later?utm_medium=google&utm_source=sem&utm_campaign=B0005P3V&kid=943800142493&gclsrc=aw.ds&gad_source=1&gad_campaignid=23358056159&gbraid=0AAAAADsjovzIMguDDS_1y3GouL0Q-NIIr&gclid=Cj0KCQjwkrzPBhCqARIsAJN460kJuhJbcCHH46KCMEnOWluSvI1PFrXh2I7hS_D4fg6jtycG5Tioua0aAoXWEALw_wcB) and Pay Monthly (https://www.paypal.com/us/digital-wallet/ways-to-pay/buy-now-pay-later?utm_medium=google&utm_source=sem&utm_campaign=B0005P3V&kid=299579192091&gclsrc=aw.ds&gad_source=1&gad_campaignid=23358056159&gbraid=0AAAAADsjovzIMguDDS_1y3GouL0Q-NIIr&gclid=Cj0KCQjwkrzPBhCqARIsAJN460k-pl1GncvfWrZXCL5FjA-9NIhuWR-akPzbhQ_WXqXOQtJt2m45TnAaAhHBEALw_wcB) options.
"Travel is one of the most meaningful ways people spend their money, and how they pay for it matters," said Anand Sivadasan, VP and Head of BNPL, PayPal. "By integrating PayPal Buy Now, Pay Later into Mindtrip's experience, we're giving consumers greater flexibility at checkout while helping travel partners drive higher engagement and conversion This is what it looks like when trusted payments meet agentic travel experiences."
To celebrate the launch and make upcoming travel plans more affordable, travelers who redeem the offer in the PayPal app and spend $250 or more using PayPal's Buy Now Pay Later options on Mindtrip can earn 5,000 points (approximate $50 value, subject to terms) after completing an eligible booking.
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About Mindtrip
Mindtrip is a travel platform that leverages proprietary AI to make travel exciting, easy and fun. Founded in 2023 in Silicon Valley, Mindtrip was developed by serial entrepreneurs and avid travelers who have a deep understanding of technology, trends, and a proven track record of bringing game-changing products to market. The company's founders created Mindtrip, a first-of-its-kind platform that combines conversational AI with a proprietary knowledge base to deliver personalized travel experiences that are accurate, actionable, and all in one place.
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About Sabre
Powering the agentic revolution in travel. Sabre is an AI-native technology leader, backed by one of the world's largest travel data clouds. With AI at its core and operating at unparalleled scale, Sabre transforms insights into innovation, empowering airlines, hoteliers, agencies and other partners to retail, distribute and fulfill travel worldwide. Sabre is built on an open, modular, cloud-native architecture and serves as the backbone for both established leaders and bold, new disruptors, guiding them to the next age of travel retailing through intelligent, connected, and personalized experiences.
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About PayPal
PayPal has been revolutionizing commerce globally for more than 25 years. Creating innovative experiences that make moving money, selling, and shopping simple, personalized, and secure. PayPal empowers consumers and businesses in approximately 200 markets across 14,000 banks globally to join and thrive in the global economy.
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Original text: https://www.sabre.com/resources/newsroom/mindtrip-launches-travels-first-all-in-one-agentic-ai-flight-booking-experience-powered-by-partnership-with-sabre-and-paypal/
[Category: BizComputer Technology]
Marcus & Millichap Brokers Hospitality Asset Sale in Suburban Syracuse
ENCINO, California, May 7 (TNSxrep) -- Marcus and Millichap issued the following news release:
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Marcus & Millichap Brokers Hospitality Asset Sale in Suburban Syracuse
EAST SYRACUSE, N.Y.- Marcus & Millichap (NYSE: MMI), a leading commercial real estate brokerage firm specializing in investment sales, financing, research and advisory services, announced today the sale of the DoubleTree Syracuse, a 250-room hotel in the Carrier Circle area of East Syracuse, New York.
"With over 17,000 square feet of meeting space, including the two largest ballrooms among the competitive set, the DoubleTree
... Show Full Article
ENCINO, California, May 7 (TNSxrep) -- Marcus and Millichap issued the following news release:
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Marcus & Millichap Brokers Hospitality Asset Sale in Suburban Syracuse
EAST SYRACUSE, N.Y.- Marcus & Millichap (NYSE: MMI), a leading commercial real estate brokerage firm specializing in investment sales, financing, research and advisory services, announced today the sale of the DoubleTree Syracuse, a 250-room hotel in the Carrier Circle area of East Syracuse, New York.
"With over 17,000 square feet of meeting space, including the two largest ballrooms among the competitive set, the DoubleTreeSyracuse provides the best facilities for meetings and events, and is well positioned to capture demand from Micron and other groups in the local market," said Andy Kern of Marcus & Millichap. "Recent supply reductions will drive demand as the 235-room Sheraton Syracuse University Hotel and the 277-room Crowne Plaza Syracuse closed in 2024 to be converted into student housing." Kern, Jerry Swon, and David Altobello of Marcus & Millichap, in association with John Horowitz, Marcus & Millichap's broker of record in New York, represented the seller and procured the buyer, both of whom are private investors.
Opened in 1977 and renovated in 2016, the DoubleTree Syracuse has one central building that contains all public areas, plus four-story and seven-story guestroom wings. Amenities include a tavern and bar, a business center, an indoor swimming pool, and a fitness center. The sale is the seventh hotel transaction completed in the Syracuse metropolitan area by Kern, Swon, and Altobello.
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About Marcus & Millichap, Inc. (NYSE: MMI)
Marcus & Millichap, Inc. is a leading brokerage firm specializing in commercial real estate investment sales, financing, research and advisory services with offices throughout the United States and Canada. As of December 31, 2025, the company had 1,808 investment sales and financing professionals in over 80 offices who provide investment brokerage and financing services to sellers and buyers of commercial real estate. The company also offers market research, consulting and advisory services to clients. Marcus & Millichap closed 8,818 transactions in 2025, with a sales volume of approximately $50.9 billion.
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Original text: https://www.marcusmillichap.com/news-events/press/2026/05/marcus-millichap-brokers-hospitality-asset-sale-in-suburban-syracuse
[Category: BizRealEstate]
CrowdStrike Recognizes 2026 Americas Partners Driving Growth With the Falcon Platform
AUSTIN, Texas, May 7 -- CrowdStrike Inc., a cybersecurity platform for protecting areas of enterprise risk - endpoints and cloud workloads, identity and data, issued the following news on May 6, 2026:
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CrowdStrike Recognizes 2026 Americas Partners Driving Growth with the Falcon Platform
AUSTIN, Texas and MIAMI - Americas Partner Symposium - May 6, 2026 - CrowdStrike (NASDAQ: CRWD) today announced the winners of the 2026 Americas Partner of the Year Awards at its annual Americas Partner Symposium, recognizing partners across the region building and scaling their businesses with the CrowdStrike
... Show Full Article
AUSTIN, Texas, May 7 -- CrowdStrike Inc., a cybersecurity platform for protecting areas of enterprise risk - endpoints and cloud workloads, identity and data, issued the following news on May 6, 2026:
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CrowdStrike Recognizes 2026 Americas Partners Driving Growth with the Falcon Platform
AUSTIN, Texas and MIAMI - Americas Partner Symposium - May 6, 2026 - CrowdStrike (NASDAQ: CRWD) today announced the winners of the 2026 Americas Partner of the Year Awards at its annual Americas Partner Symposium, recognizing partners across the region building and scaling their businesses with the CrowdStrikeFalcon(R) platform.
As organizations consolidate security in the AI era, CrowdStrike's global ecosystem of partners help customers move from fragmented tools onto a unified, AI-native platform to reduce complexity and stop breaches. CrowdStrike's Americas Partner Awards recognize outstanding contributions from the previous calendar year, based on the value partners delivered to customers and the broader CrowdStrike ecosystem. This year's award winners span global system integrators, cloud providers, MSSPs, and distributors that deploy and expand the Falcon platform.
2026 CrowdStrike Americas Partner Awards winners include:
* GuidePoint Security - Americas Partner of the Year
* Accenture - Americas Innovation Excellence Award
* Amazon Web Services (AWS) - Americas Falcon Partner of the Year
* Blackwood - Americas Regional Growth Partner of the Year
* Carahsoft - Americas Strategic Distribution Partner of the Year
* Cognizant - Americas Velocity Partner of the Year
* Consortium - Americas Technical Champion of the Year
* Ernst & Young LLP (EY US) - Americas GSI of the Year
* Kroll - Americas MSSP Partner of the Year
* NVIDIA - Americas Visionary Leadership Award
* Presidio - Americas Specialized Solutions Partner of the Year
* ThunderCat Technology - Americas Sales MVP of the Year
* Zscaler - Americas Ecosystem Partner of the Year
"Partners aren't just selling the CrowdStrike Falcon platform, they're building and scaling high-growth businesses on it," said Amanda Adams, senior vice president of global alliances at CrowdStrike. "As customers standardize on the platform, partners are expanding with them - building services, driving adoption, and delivering outcomes. At the end of the day, this market comes down to stopping breaches, and our partners are critical to delivering that at scale. This year's winners represent the strength and momentum of this ecosystem."
For more information on CrowdStrike's partner ecosystem, visit here (https://www.crowdstrike.com/en-us/partner-program/).
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About CrowdStrike
CrowdStrike (NASDAQ: CRWD), a global cybersecurity leader, has redefined modern security with the world's most advanced cloud-native platform for protecting critical areas of enterprise risk - endpoints and cloud workloads, identity and data.
Powered by the CrowdStrike Security Cloud and world-class AI, the CrowdStrike Falcon(R) platform leverages real-time indicators of attack, threat intelligence, evolving adversary tradecraft, and enriched telemetry from across the enterprise to deliver hyper-accurate detections, automated protection and remediation, elite threat hunting, and prioritized observability of vulnerabilities.
Purpose-built in the cloud with a single lightweight-agent architecture, the Falcon platform delivers rapid and scalable deployment, superior protection and performance, reduced complexity, and immediate time-to-value.
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Original text here: https://www.crowdstrike.com/en-us/press-releases/2026-americas-partner-awards-winners/
[Category: BizComputer Technology]
Bayer Announces New Late-breaking Data From OCEANIC-STROKE Trial of Asundexian
WHIPPANY, New Jersey, May 7 -- Bayer USA, an enterprise with core competencies in the life science fields of health care and nutrition, issued the following news on May 6, 2026:
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Bayer announces new late-breaking data from OCEANIC-STROKE trial of asundexian
Data evaluates the frequency, severity, and disability of ischemic strokes in patients after a non-cardioembolic ischemic stroke or high-risk transient ischemic attack
KEY FINDINGS
* The Phase III OCEANIC-STROKE study, previously published in The New England Journal of Medicine, met the primary efficacy outcome of time to first occurrence
... Show Full Article
WHIPPANY, New Jersey, May 7 -- Bayer USA, an enterprise with core competencies in the life science fields of health care and nutrition, issued the following news on May 6, 2026:
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Bayer announces new late-breaking data from OCEANIC-STROKE trial of asundexian
Data evaluates the frequency, severity, and disability of ischemic strokes in patients after a non-cardioembolic ischemic stroke or high-risk transient ischemic attack
KEY FINDINGS
* The Phase III OCEANIC-STROKE study, previously published in The New England Journal of Medicine, met the primary efficacy outcome of time to first occurrenceof ischemic stroke and the primary safety outcome of time to ISTH (International Society on Thrombosis and Haemostasis) major bleeding
* New analyses from OCEANIC-STROKE trial evaluate stroke severity and disability in patients treated with investigational asundexian who experienced an ischemic stroke during the trial compared to placebo, both in combination with antiplatelet therapy
* In a new analysis, acute treatment with intravenous thrombolysis (IVT) / endovascular treatment (EVT) and fatality outcomes of incident ischemic strokes were examined in patients taking asundexian compared to placebo; the analysis provides interesting insights but was not designed to provide statistical confirmatory evidence
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Bayer today announced late-breaking data from new analyses of the landmark Phase III OCEANIC-STROKE study of asundexian compared to placebo, both in combination with antiplatelet therapy. The study, presented at the European Stroke Organisation Conference (ESOC) 2026 in Maastricht, the Netherlands, analyzed the frequency, severity, and disability of ischemic stroke in patients after a non-cardioembolic ischemic stroke or high-risk transient ischemic attack. Among patients who experienced an ischemic stroke during the study:
* The proportion of patients with a National Institutes of Health Stroke Scale (NIHSS) score 8 was lower with asundexian than placebo (22.9% vs 30.3%; p=0.045).
* Patients taking asundexian had numerically fewer disabling strokes (2.1% vs 3.0%; csHR 0.69; 95% CI 0.55-0.87) compared to placebo.
WHY THIS MATTERS
Stroke is the fifth leading cause of death in the United States./1 Each year, approximately 795,000 people in the United States will experience a stroke. Of these, approximately 87% are ischemic and 23% are recurrent./2 Despite current guideline recommended treatment options for stroke prevention, a significant proportion of survivors experience another stroke./3,/4 Approximately one in five stroke survivors will have another stroke within five years./4
"When a patient has another stroke, we know those events are often more severe and more likely to result in disability. These new analyses about stroke severity and disabling stroke are highly relevant to the stroke community as we continue to evaluate multiple aspects of asundexian in the OCEANIC-STROKE study." - Ashkan Shoamanesh, Co-principal Investigator of the OCEANIC-STROKE study, and Senior Scientist at Population Health Research Institute, a joint institute of McMaster University and Hamilton Health Sciences
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OCEANIC-STROKE STUDY ANALYSES DESIGN
In OCEANIC-STROKE, 902 incident ischemic strokes occurred during the study (asundexian, n=384 [6.2%]; placebo, n=518 [8.4%]) and were evaluated for stroke severity and whether they were classified as disabling / fatal. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) during hospitalization and stratified by score (3, 4-7, and 8). Disabling stroke was defined as a modified Rankin Scale (mRS) 3 or a 1 point increase in mRS for patients with a baseline mRS 3.
KEY FINDINGS OF NEW ANALYSES FROM OCEANIC-STROKE TRIAL
* Stroke severity: Among incident ischemic strokes, moderate-to-high severity strokes (NIHSS 8) occurred in 88 patients (22.9%) in the asundexian group and 157 patients (30.3%) in the placebo group.
* Disabling / fatal stroke risk: The occurrence of disabling stroke was 2.1% (n=128) in the asundexian group and 3.0% (n=185) in the placebo group (csHR, 0.69; 95% CI: 0.55-0.87).
* Acute intervention: Of the ischemic strokes that did occur, 40 patients (10.4%) required acute intervention (intravenous thrombolysis [IVT] and/or endovascular treatment [EVT]) in the asundexian group, and 82 patients (15.8%) required acute intervention (IVT and / or EVT) in the placebo group.
* Ischemic stroke treated with EVT use: In patients who experienced an incident ischemic stroke, 27 patients (0.4%) required EVT in the asundexian group and 44 patients (0.7%) required EVT in the placebo group (csHR, 0.61; 95% CI: 0.38-0.99).
* Ischemic stroke with fatal outcomes: In patients who experienced an incident ischemic stroke, 16 patients (0.3%) experienced fatal outcomes in the asundexian group, and 28 patients (0.5%) experienced fatal outcomes in the placebo group (csHR, 0.57; 95% CI: 0.31-1.06).
BAYER EXECUTIVE COMMENT
"Stroke is one of the most pressing global health challenges, with serious and lasting consequences for patients, families, and healthcare systems around the world," said Sara Hegab, MD, VP, Stroke & Thrombosis, Specialty and Pipeline, U.S. Medical Affairs, Bayer. "OCEANIC-STROKE reflects the strength of Bayer's capabilities to take on complex global health challenges like stroke and the impact we hope to offer to patients. The insights from this study will continue to contribute to a deeper understanding of secondary stroke and the outcomes associated with these events."
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About OCEANIC-STROKE
The Phase III OCEANIC-STROKE study investigated the efficacy and safety of the oral Factor XIa inhibitor asundexian 50 mg once-daily compared to placebo, both in combination with antiplatelet therapy, for prevention of ischemic stroke in patients after a non-cardioembolic ischemic stroke or high-risk transient ischemic attack (TIA). It is a multicenter, international, randomized, placebo-controlled, double-blind, parallel group and event-driven study, that randomized 12,327 participants worldwide. The primary efficacy endpoint was time to first occurrence of ischemic stroke; the primary safety endpoint was time to ISTH major bleeding.
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About FXIa
Factor XIa (FXIa) is a protein in the blood coagulation pathway, also known as the blood clotting process, with different roles in hemostasis (normal clotting to stop bleeding) and thrombosis (harmful clot formation that can block blood vessels). FXIa has a minor role in the formation of a hemostatic plug (a clot that seals a blood vessel injury) that seals the leak at the site of vessel injury. However, FXIa is thought to contribute to the formation of pathological thrombus growth (abnormal clot growth) and vessel blockage.
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About Bayer's Commitment in Cardiovascular and Cerebrovascular Medicine
Bayer is a leader in cardiology and is advancing a portfolio of innovative treatments in cardiovascular (CV) and cerebrovascular diseases of high unmet medical need. We have set a clear focus on developing innovative therapies to treat such diseases (e.g., stroke, heart failure, cardiomyopathies, and chronic kidney disease) and it is our ambition to take a leading role in the care of patients with these diseases. Bayer is actively shaping the future of cardiology and neurology with a robust and diversified pipeline, strategically positioned to address critical unmet needs and drive significant long-term value. Bayer's portfolio already includes several innovative products and compounds in various stages of preclinical and clinical development.
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About Bayer
Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. In line with its mission, "Health for all, Hunger for none," the company's products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2025, the Group employed around 88,000 people and had sales of 45.3 billion euros. R&D expenses amounted to 5.8 billion euros.
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Forward-Looking Statements
This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer's public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.
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References:
1. Martin SS, et al. Circulation. 2024;149(8):e347-e913.
2. Virani SS, et al. Circulation. 2021;143:e254-e743
3. Kolmos M, et al. J Stroke Cerebrovasc Dis. 2021;30(8):105935.
4. Lakshminarayan K, et al. Stroke. 2011;42(6):1556-1562.
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Original text here: https://www.bayer.com/en/us/news-stories/data-from-oceanic-stroke-trial-of-asundexian
[Category: BizPharmaceuticals]
