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DEA Amends Regulations for Controlled Substances Ordering System
October 02, 2025
WASHINGTON, Oct. 2 (TNSFR) -- The U.S. Department of Justice Drug Enforcement Administration is amending its regulations to require that all Controlled Substances Ordering System (CSOS) enrollment applications and supporting materials be submitted through the Diversion Control Division's secure online portal.

The purpose of the rule is to simplify the application process for registrants who wish to use CSOS, which is the secure electronic equivalent of the paper DEA Form 222 us . . .

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